Calculator Acute Myeloid Leukemia- Composite Model

Instructions

Each section has additional instructions which you can display by clicking on the section's icon.
Please check a box or enter a value as it applies to the patient's condition- keeping in mind that in order the for the model to be accurate, all necessary components need to be entered.
Click on one of the buttons at the bottom of the page to calculate the score or save your entries for later.

You need to correct the following errors before a score can be calculated:

A) Augmented HCT-CI

1. Arrhythmia (score = 1) Arrhythmia section help

Atrial fibrillation

Yes

Atrial flutter

Yes

Supraventricular tachycardia

Yes

Sick sinus syndrome

Yes

Heart block

Yes

Ventricular arrhythmia

Yes

Other, specify:

Yes

2. Cardiovascular Score (score = 1) Cardiovascular Score section help

Coronary artery disease

Yes

Congestive heart failure

Yes

Ejection fraction

Shortening fraction (for pediatrics)

3. Inflammatory Bowel Disease (score = 1) Inflammatory Bowel Disease section help

Crohn's disease

Yes

Ulcerative colitis

Yes

4. Diabetes (score = 1) Diabetes section help

Diabetes

Yes

Steroid-induced hyperglycemia

Yes

5. Cerebro-Vascular Disease (score = 1) Cerebro-Vascular Disease section help

Transient ischemic attack

Yes

Subarachnoid hemorrhage

Yes

Cerebral thrombosis

Yes

Cerebral embolism

Yes

Cerebral hemorrhage

Yes

6. Psychiatric Disturbance (score = 1) Psychiatric Disturbance section help

Depression

Yes

Anxiety

Yes

Other, specify:

Yes

7. Hepatic Comorbidity (score = 1 or 3) Hepatic Score section help

Total bilirubin:

upper limit of normal value:

Bilirubin patient value:

Aspartate transaminase (AST):

upper limit of normal value:

AST patient value:

Alanine transaminase (ALT):

upper limit of normal value:

ALT patient value:

Alkaline Phosphatase (ALK):

upper limit of normal value:

ALK patient value:

Hepatitis B

Yes

Hepatitis C

Yes

Liver cirrhosis or fibrosis

Yes

8. Obesity (score = 1) Obesity section help

Patient height (cm):

Patient weight (kg):

Calculated BMI:

BMI-for-age percentile, for patients <= 18 yr old:

9. Infection (score = 1) Infection section help

Documented infection

Yes

Fever of unknown origin

Yes

Pumonary nodules suspicious of fungal pneumonia

Yes

PPD positive requiring TB prophlaxis

Yes

Other, specify:

Yes

10. Rheumatologic Score (score = 2) Rheumatologic Score section help

Systemic lupus erythematosus

Yes

Rheumatoid arthritis

Yes

Polymyositis

Yes

Mixed connective tissue disease

Yes

Polymyalgia rheumatica

Yes

Other, specify:

Yes

11. Peptic Ulcer (score = 2) Peptic ulcer section help

Gastric ulcer

Yes

Duodenal ulcer

Yes

12. Renal Comorbidity (score = 2) Renal Score section help

Creatinine clearance patient value:

ml/min

Serum Creatinine
Please select units and enter value

Creatinine units:

mg/dL

umol/L

ii.

Serum creatinine patient value:

Patient on dialysis

Yes

Prior renal transplantation

Yes

13. Pulmonary Score (score = 2 or 3) Pulmonary Score section help

Diffusion capacity of carbon monoxide (DLco)
Please enter items i and ii

Percentage of measured uncorrected DLco divided by predicted DLco:

ii.

Concurrent hemoglobin value:

g/dl

iii.

Calculated pct of corrected DLco (Dinakara equation):

Forced expiratory volume in 1 second (FEV1)
Please enter enter a value

Percentage of measured forced expiratory volume in 1 second (FEV1) divided by predicted FEV1:

Shortness of breath on slight activity

Yes

Shortness of breath at rest

Yes

Oxygen supplementation

Yes

14. Prior Solid Tumor (score = 3) Prior Solid Tumor section help

Prior solid tumor, type:

Yes

15. Heart Valve Disease (score = 3) Heart Valve Disease section help

Valve stenosis, type of valve:

Yes

Valve insufficiency, type of valve:

Yes

Prosthetic valve, type of valve:

Yes

Symptomatic mitral valve prolapse:

Yes

16. Hypoalbuminemia (score = 1) Hypoalbuminemia section help

Albumin patient value

17. Elevated LDH (score = 1 or 2) Elevated LDH section help

LDH patient value

U/L

B) Patient Age

Patient Age

C) Cytogenetic-molecular risks per ELN 2017 Classification

A. Favorable risk (score = 0)

t(8;21)

Yes

II.

inv(16)

Yes

III.

t(16;16)

Yes

IV.

Mutated NPM1 (counted if either of the two situations below are true)

FLT3-ITD

No or

ii.

FLT3-ITD present but low (allelic ratio is <0.5)

Yes

Biallelic mutated CEBPA

Yes

B. Intermediate risk (score = 1)

Mutated NPM1 (counted if either of the two situations below are true)

FLT3-ITD present (high: meaning allelic ratio is >0.5)

Yes or

ii.

FLT3-ITD present (unknown allelic)

Yes

II.

Wild type NPM1 (counted if either of the two situations below are true)

FLT3-ITD

ii.

FLT3-ITD present but low (allelic ratio is <0.5)

Yes

III.

t(9;11)

Yes

IV.

Cytogenetic abnormalities not classified as favorable or adverse

Yes

C. Adverse risk (score = 3)

t(6;9)

Yes

II.

t(v;11q23.3)

Yes

III.

t(9.22)

Yes

IV.

inv(3) or t(3;3)(q21.3;q26.2);GATA2,MECOM(EVI1)

Yes

-5 or del(5q);-7;-17

Yes

VI.

monosomal karyotype Monosomal Karyotype help

Yes

VII.

complex karyotype Complex Karyotype help

Yes

VIII.

Wild type NPM1 and FLT3-ITD (Meaning allelic ratio is >0.5)

Yes

IX.

mutated RUNX1

Yes

mutated ASXL1

Yes

XI.

mutated TP53

Yes